Anti-CCP (Anti-Cyclic Citrullinated Peptide)
Autoantibody highly specific for rheumatoid arthritis. More specific than RF; may appear years before clinical RA.
Test Information
Reports In
Same day (6 hours)
Parameters
1
Requisites
Blood Sample
Sample Type
Blood
Measures
Antibodies against citrullinated peptides
Identifies
Rheumatoid arthritis—highly specific; often positive before symptoms
What is the Anti-CCP Test?
Anti-CCP (Anti-Cyclic Citrullinated Peptide) antibodies are the most specific blood marker for Rheumatoid Arthritis. While RF can be elevated in many conditions, Anti-CCP is highly specific to RA. It can be positive years before symptoms appear, making it valuable for early diagnosis and predicting disease severity.
Why Should You Take This Test?
Anti-CCP is 95%+ specific for RA. Positive result with joint symptoms strongly supports diagnosis and may predict more erosive disease.
Who Should Get Tested?
Suspected Rheumatoid Arthritis
Most specific RA blood test.
RF-Positive Patients
Confirms RA diagnosis alongside RF.
Family History of RA
Early detection before symptoms.
Warning Signs — When Should You Get This Test?
Common Conditions Detected
Frequently Booked Together
Tests commonly ordered alongside Anti-CCP for a complete picture
RF
Combined RF + Anti-CCP increases diagnostic accuracy
ESR/CRP
Inflammation markers for disease activity
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